Siamon Gordon, University of Oxford, UK
Bruce A. Beutler

Siamon Gordon (aka Saimon) was born in Cape Town, South Africa, 29 April, 1938.He graduated from the University of Cape Town Medical School in 1961.After a year at the Wright-Fleming Institute, London, in the department of Rodney Porter, he spent 10 years at Rockefeller University, New York, first with Alexander Bearn as a postdoctoral scientist, then as doctoral student with Zanvil Cohn. His PhD on macrophage cell fusion was completed in 1971.He was an assistant Professor at Rockefeller till 1976, when he joined the Sir William Dunn School of Pathology in Oxford in 1976, as Reader in Experimental Pathology, progressing to Professor of Cellular Pathology. He was elected to Honorary Membership of the American Association of Immunology, to Fellowship of the Royal Society and the Academy of Medical Science. He has received various prizes, including the Bonazinga award. He retired in 2008, but remained active in research and writing.

He received an Honorary doctorate from the University of Cape Town, where he has been involved in a Research Institute of Infectious Disease for the past decade. During this period he initiated an AIDS prevention project, which included publication of an educational cartoon booklet. He has mentored a number of research students and post-doctoral scientists, including from South Africa.

His research focused on macrophage heterogeneity, differentiation and activation, during development, infection and metabolic disease. His interest in cell fusion lead to the development of a range of monoclonal antibodies to study macrophages in tissues such as bone marrow, spleen and the nervous system. The functional significance of macrophage receptors and giant cell formation remained an interest to the present.

As Emeritus he has been immersed in history of macrophage research, from Metchnikoff to the discovery of Dendritic cells by Steinman and Cohn.

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